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Breaks actimeter2/27/2024 ![]() According to the World Health Organization, CVD was the second leading cause of death in the world in 2014 behind ischemic heart disease. Stroke, a cerebrovascular disease (CVD), is the main cause of temporary or permanent neurologic disabilities in individuals aged 50 years and older. We conclude that a TCI temperature of 400☌ causes permanent ischemic stroke and motor deficit. The MRI and TTC analyses revealed that ischemic brain lesions expressively evolved, especially at TCI temperatures of 300☌ and 400☌, and significant motor deficits were observed as the animals showed a decrease frequency of movement and an asymmetric pattern. In the second experiment, five groups ( n = 5 each) were analyzed by MRI (basal and 24 h after TCI) and behavioral tests (basal and seven days after TCI) with the control group added for the surgical effects. In the first experiment, the animals were divided into four groups ( n = 5 each): one sham surgery group and three ischemic lesion groups having thermocoagulation induction (TCI) temperatures of 200☌, 300☌, and 400☌, respectively, with blood perfusion (basal and 30 min after TCI) and 2,3,5-Triphenyl-tetrazolium chloride (TTC) evaluation at 2 h after TCI. We used three-month-old male Wistar rats, weighing 300–350 g. We investigated parameters such as temperature and thermal dissipation in the brain tissue during induction and analyzed real-time blood perfusion, histological changes, magnetic resonance imaging (MRI), and motor behavior in a permanent ischemic stroke model. This study analyzed the best conditions for inducing a focal ischemic lesion by thermocoagulation. The thermocoagulation model, which consists of focal cerebral ischemia with craniectomy, is helpful in studying permanent ischemic brain lesions and has good reproducibility and low mortality. Gamarra, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing 1, 2, * Nucci, Formal analysis, Validation, Visualization, Writing – original draft, 1, 5 Alberto Tannus, Data curation, Investigation, Software, Visualization, 6 and Lionel F. Mamani, Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing, 1 Rosalia Mendez-Otero, Conceptualization, Methodology, Supervision, Validation, Visualization, Writing – original draft, 4 Leopoldo P. Nucci, Conceptualization, Data curation, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing, 3 Javier B. Helio da Silva, Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing, 1, 2 Mariana P.
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